American geneticist. Showed in 1927 that mutations could be induced by radiation. Clarified modern definition of the term "mutation." Defended the "classical" genetic argument that because most mutations are very deleterious, most loci are homozygous. Suggested that the production of imbalanced sets of sex determining chromosomes would lead to polyploidy being rare in sexual organisms. Muller was awarded the Nobel Prize in medicine in 1946. A left-wing eugenicist before World War II.
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